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Director
Bridget R. Mueller, MD, PhD
Principal Investigator
Bridget Mueller, MD, PhD is a physician–scientist and Associate Professor of Neurology at the Icahn School of Medicine at Mount Sinai in New York City. She serves as the Research Director of the David S. and Ruth L. Gottesman Center for Headache Treatment and Translational Research at the Icahn School of Medicine at Mount Sinai (ISMMS) and co-directs the Mount Sinai Autonomic Laboratory.
Dr. Mueller has made significant scientific contributions across both basic and clinical research, advancing our understanding of how biological systems shape pain, stress, and neurological health. As a bench researcher, she was among the first to demonstrate how prenatal stress early in pregnancy alters the placenta and developing brain, disrupting key pathways that regulate stress responses, mood, cognition, and metabolism. Her work also revealed that both the timing of stress exposure and the biological sex of the fetus play critical roles in determining long-term neurological outcomes—findings that have helped redefine how scientists conceptualize early-life influences on brain development.
Building on her bench neuroscience training,, Dr. Mueller’s research now aims to transform how migraine and chronic pain are understood and treated by shifting the field from symptom-based classifications to pathophysiology-driven definitions. Dr. Mueller’s research also focuses on studying non-pharmacalogic therapies, including neuromodulation and biofeedback, for migraine treatment. Her multidisciplinary research program integrates advanced neuroimaging, autonomic testing, and clinical phenotyping to identify mechanisms that drive pain chronification. This work is designed to identify new therapeutic targets and support precision medicine approaches that match the right treatment to the right patient at the right time.
Dr. Mueller treats patients at the David S. and Ruth L. Gottesman Center for Headache Treatment and Translational Research at ISMMS.
